Quantitative Evaluation of the Regenerated Dura Mater in a Decompressive Skull Trepanation Model in Rats

Regeneration of the dura mater following duraplasty using a collagen film, chitosan or combination both with gelatin, was studied in craniotomy and penetrating brain injury model rats. Collagen autofluorescence regenerated evaluated confocal microscopy excitation at λem = 488 nm 543 nm. An increase regeneration extracellular matrix connective tissue an fluorescence were detected 6 weeks after duraplasty. The major contributors to films, plus gelatin-based and, much lesser extent, chitosan-based films. By densitometry matrix, authors able quantify degree